Frontal fasciculi and psychotic symptoms in antipsychotic-naive patients with schizophrenia before and after 6 weeks of selective dopamine D2/3 receptor blockade | Zendy

Bjørn H. Ebdrup | Zendy; Jayachandra M. Raghava | Zendy; Mette Ødegaard Nielsen | Zendy; Egill Rostrup | Zendy; Birte Glenthøj | Zendy

Open Access

Frontal fasciculi and psychotic symptoms in antipsychotic-naive patients with schizophrenia before and after 6 weeks of selective dopamine D2/3 receptor blockade

Author(s) -

Bjørn H. Ebdrup,

Jayachandra M. Raghava,

Mette Ødegaard Nielsen,

Egill Rostrup,

Birte Glenthøj

Publication year - 2016

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.150030

Subject(s) - fractional anisotropy , white matter , cingulum (brain) , psychology , schizophrenia (object oriented programming) , medicine , superior longitudinal fasciculus , psychosis , arcuate fasciculus , dopamine receptor d2 , amisulpride , antipsychotic , neuroscience , cardiology , magnetic resonance imaging , psychiatry , dopamine , radiology

Psychotic symptoms are core clinical features of schizophrenia. We tested recent hypotheses proposing that psychotic, or positive, symptoms stem from irregularities in long-range white matter tracts projecting into the frontal cortex, and we predicted that selective dopamine D2/3 receptor blockade would restore white matter.

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