Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour | Zendy

Elsa Isingrini | Zendy; Léa C. Perret | Zendy; Quentin Rainer | Zendy; Sara Sagueby | Zendy; Luc Moquin | Zendy; Alain Gratton | Zendy; Bruno Giros | Zendy

Open Access

Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour

Author(s) -

Elsa Isingrini,

Léa C. Perret,

Quentin Rainer,

Sara Sagueby,

Luc Moquin,

Alain Gratton,

Bruno Giros

Publication year - 2016

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.150028

Subject(s) - monoaminergic , serotonergic , neurochemical , dopaminergic , dopamine , vesicular monoamine transporter , neuroscience , monoamine neurotransmitter , serotonin , vesicular monoamine transporter 2 , amphetamine , neurotransmission , biology , endocrinology , medicine , psychology , dopamine transporter , genetics , receptor

The monoaminergic transmitters dopamine (DA), noradrenaline (NE) and serotonin (5-HT) modulate cerebral functions via their extensive effects in the brain. Investigating their roles has led to the creation of vesicular monoaminergic transporter-2 (VMAT2) knockout (KO) mice. While this mutation results in postnatal death, VMAT2-heterozygous (HET) mice are viable and show a complex behavioural phenotype. However, the simultaneous alteration of the 3 systems prevents investigations into their individual functions.

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