Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings | Zendy

Janita Bralten | Zendy; Corina U. Greven | Zendy; Barbara Franke | Zendy; Maarten Mennes | Zendy; Marcel P. Zwiers | Zendy; Nanda Rommelse | Zendy; Catharina A. Hartman | Zendy; Dennis van der Meer | Zendy; Laurence O’Dwyer | Zendy; Jaap Oosterlaan | Zendy; Pieter J. Hoekstra | Zendy; Dirk J. Heslenfeld | Zendy; Alejandro Arias Väsquez | Zendy; Jan K. Buitelaar | Zendy

Open Access

Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings

Author(s) -

Janita Bralten,

Corina U. Greven,

Barbara Franke,

Maarten Mennes,

Marcel P. Zwiers,

Nanda Rommelse,

Catharina A. Hartman,

Dennis van der Meer,

Laurence O’Dwyer,

Jaap Oosterlaan,

Pieter J. Hoekstra,

Dirk J. Heslenfeld,

Alejandro Arias Väsquez,

Jan K. Buitelaar

Publication year - 2016

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.140377

Subject(s) - precentral gyrus , grey matter , voxel based morphometry , psychology , orbitofrontal cortex , superior frontal gyrus , attention deficit hyperactivity disorder , cognition , voxel , brain size , neuroimaging , audiology , superior temporal gyrus , clinical psychology , neuroscience , medicine , prefrontal cortex , magnetic resonance imaging , functional magnetic resonance imaging , white matter , radiology

Data on structural brain alterations in patients with attention-deficit/hyperactivity disorder (ADHD) have been inconsistent. Both ADHD and brain volumes have a strong genetic loading, but whether brain alterations in patients with ADHD are familial has been underexplored. We aimed to detect structural brain alterations in adolescents and young adults with ADHD compared with healthy controls. We examined whether these alterations were also found in their unaffected siblings, using a uniquely large sample.

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