The hippocampi of children with chromosome 22q11.2 deletion syndrome have localized anterior alterations that predict severity of anxiety | Zendy

Julia A. Scott | Zendy; Naomi J. GoodrichHunsaker | Zendy; Kristopher Kalish | Zendy; Aaron Lee | Zendy; Michael R. Hunsaker | Zendy; Cynthia M. Schumann | Zendy; Owen Carmichael | Zendy; Tony J. Simon | Zendy

Open Access

The hippocampi of children with chromosome 22q11.2 deletion syndrome have localized anterior alterations that predict severity of anxiety

Author(s) -

Julia A. Scott,

Naomi J. GoodrichHunsaker,

Kristopher Kalish,

Aaron Lee,

Michael R. Hunsaker,

Cynthia M. Schumann,

Owen Carmichael,

Tony J. Simon

Publication year - 2016

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.140299

Subject(s) - hippocampal formation , hippocampus , anxiety , psychology , neuroscience , psychosis , schizophrenia (object oriented programming) , cognition , medicine , psychiatry

Individuals with 22q11.2 deletion syndrome (22q11.2DS) have an elevated risk for schizophrenia, which increases with history of childhood anxiety. Altered hippocampal morphology is a common neuroanatomical feature of 22q11.2DS and idiopathic schizophrenia. Relating hippocampal structure in children with 22q11.2DS to anxiety and impaired cognitive ability could lead to hippocampus-based characterization of psychosis-proneness in this at-risk population.

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