Monocyte and microglial activation in patients with mood-stabilized bipolar disorder | Zendy

Joel Jakobsson | Zendy; Maria Bjerke | Zendy; Sara Sahebi | Zendy; Anniella Isgren | Zendy; Carl Johan Ekman | Zendy; Carl M. Sellgren | Zendy; Bob Olsson | Zendy; Henrik Zetterberg | Zendy; Kaj Blennow | Zendy; Erik Pålsson | Zendy; Mikael Landén | Zendy

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Monocyte and microglial activation in patients with mood-stabilized bipolar disorder

Author(s) -

Joel Jakobsson,

Maria Bjerke,

Sara Sahebi,

Anniella Isgren,

Carl Johan Ekman,

Carl M. Sellgren,

Bob Olsson,

Henrik Zetterberg,

Kaj Blennow,

Erik Pålsson,

Mikael Landén

Publication year - 2015

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.140183

Subject(s) - bipolar disorder , confounding , cerebrospinal fluid , medicine , body mass index , neuroinflammation , mood , inflammation , endocrinology , immunology , psychiatry

Bipolar disorder is associated with medical comorbidities that have been linked to systemic inflammatory mechanisms. There is, however, limited evidence supporting a role of neuroinflammation in bipolar disorder. Here we tested whether microglial activation and associated tissue remodelling processes are related to bipolar disorder by analyzing markers in cerebrospinal fluid (CSF) and serum from patients and healthy controls.

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