Lower white matter microstructure in the superior longitudinal fasciculus is associated with increased response time variability in adults with attention-deficit/hyperactivity disorder | Zendy

Thomas Wolfers | Zendy; A. Marten H. Onnink | Zendy; Marcel P. Zwiers | Zendy; Alejandro Arias Väsquez | Zendy; Martine Hoogman | Zendy; Jeanette C. Mostert | Zendy; Cornelis C. Kan | Zendy; Dorine SlaatsWillemse | Zendy; Jan K. Buitelaar | Zendy; Barbara Franke | Zendy

Open Access

Lower white matter microstructure in the superior longitudinal fasciculus is associated with increased response time variability in adults with attention-deficit/hyperactivity disorder

Author(s) -

Thomas Wolfers,

A. Marten H. Onnink,

Marcel P. Zwiers,

Alejandro Arias Väsquez,

Martine Hoogman,

Jeanette C. Mostert,

Cornelis C. Kan,

Dorine SlaatsWillemse,

Jan K. Buitelaar,

Barbara Franke

Publication year - 2015

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.140154

Subject(s) - fractional anisotropy , fasciculus , superior longitudinal fasciculus , uncinate fasciculus , white matter , diffusion mri , attention deficit hyperactivity disorder , inferior longitudinal fasciculus , psychology , cingulum (brain) , neuroscience , audiology , medicine , psychiatry , magnetic resonance imaging , radiology

Response time variability (RTV) is consistently increased in patients with attention-deficit/hyperactivity disorder (ADHD). A right-hemispheric frontoparietal attention network model has been implicated in these patients. The 3 main connecting fibre tracts in this network, the superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus (ILF) and the cingulum bundle (CB), show microstructural abnormalities in patients with ADHD. We hypothesized that the microstructural integrity of the 3 white matter tracts of this network are associated with ADHD and RTV.

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