The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study | Zendy

Blanca Gutiérrez | Zendy; Juan Ángel Bellón | Zendy; Margarita Rivera | Zendy; Esther Molina | Zendy; Michael King | Zendy; Louise Marston | Zendy; Francisco TorresGonzález | Zendy; Berta MorenoKüstner | Zendy; Patrícia Moreno-Peral | Zendy; Emma Motrico | Zendy; Carmen Montón-Franco | Zendy; María Josefa GildeGómez-Barragán | Zendy; Marta Sánchez-Celaya | Zendy; Miguel Ángel Díaz-Barreiros | Zendy; Caterina Vicens | Zendy; Juan de Dios Luna | Zendy; Irwin Nazareth | Zendy; Jorge A. Cervilla | Zendy

Open Access

The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study

Author(s) -

Blanca Gutiérrez,

Juan Ángel Bellón,

Margarita Rivera,

Esther Molina,

Michael King,

Louise Marston,

Francisco TorresGonzález,

Berta MorenoKüstner,

Patrícia Moreno-Peral,

Emma Motrico,

Carmen Montón-Franco,

María Josefa GildeGómez-Barragán,

Marta Sánchez-Celaya,

Miguel Ángel Díaz-Barreiros,

Caterina Vicens,

Juan de Dios Luna,

Irwin Nazareth,

Jorge A. Cervilla

Publication year - 2015

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.140097

Subject(s) - 5 httlpr , serotonin transporter , psychology , depression (economics) , clinical psychology , sexual abuse , psychiatry , population , brain derived neurotrophic factor , allele , vulnerability (computing) , poison control , oncology , medicine , neurotrophic factors , injury prevention , genetics , genotype , biology , gene , receptor , macroeconomics , environmental health , economics , computer security , computer science

There is limited evidence for a moderating role of both serotonin transporter (SERT) and brain-derived neurotrophic factor (BDNF) genes on the risk for major depression (MD) developing after childhood maltreatment. However, research on this topic remains inconclusive, and there is a lack of data from longitudinal studies with large and representative population samples. Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD.

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