Grey matter, an endophenotype for schizophrenia? A voxel-based morphometry study in siblings of patients with schizophrenia | Zendy

Jorien van der Velde | Zendy; Paula M. Gromann | Zendy; Marte Swart | Zendy; Lieuwe de Haan | Zendy; Durk Wiersma | Zendy; Richard Bruggeman | Zendy; Lydia Krabbendam | Zendy; André Alemán | Zendy

Open Access

Grey matter, an endophenotype for schizophrenia? A voxel-based morphometry study in siblings of patients with schizophrenia

Author(s) -

Jorien van der Velde,

Paula M. Gromann,

Marte Swart,

Lieuwe de Haan,

Durk Wiersma,

Richard Bruggeman,

Lydia Krabbendam,

André Alemán

Publication year - 2015

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.140064

Subject(s) - grey matter , endophenotype , voxel based morphometry , schizophrenia (object oriented programming) , psychology , subclinical infection , voxel , psychosis , physiology , magnetic resonance imaging , medicine , psychiatry , cognition , radiology , white matter

Grey matter, both volume and concentration, has been proposed as an endophenotype for schizophrenia given a number of reports of grey matter abnormalities in relatives of patients with schizophrenia. However, previous studies on grey matter abnormalities in relatives have produced inconsistent results. The aim of the present study was to examine grey matter differences between controls and siblings of patients with schizophrenia and to examine whether the age, genetic loading or subclinical psychotic symptoms of selected individuals could explain the previously reported inconsistencies.

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