Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline | Zendy

Sarah Gourmaud | Zendy; Claire Paquet | Zendy; Julien Dumurgier | Zendy; Clarisse Pace | Zendy; Constantin Bouras | Zendy; Françoise Gray | Zendy; Jean Laplanche | Zendy; Éliane Meurs | Zendy; François MoutonLiger | Zendy; Jacques Hugon | Zendy

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Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline

Author(s) -

Sarah Gourmaud,

Claire Paquet,

Julien Dumurgier,

Clarisse Pace,

Constantin Bouras,

Françoise Gray,

Jean Laplanche,

Éliane Meurs,

François MoutonLiger,

Jacques Hugon

Publication year - 2015

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.140062

Subject(s) - senile plaques , cerebrospinal fluid , cognitive decline , alzheimer's disease , pathology , neurodegeneration , disease , kinase , tauopathy , medicine , degenerative disease , endocrinology , biology , dementia , biochemistry

Alzheimer disease is characterized by cognitive decline, senile plaques of β-amyloid (Aβ) peptides, neurofibrillary tangles composed of hyperphosphorylated τ proteins and neuronal loss. Aβ and τ are useful markers in the cerebrospinal fluid (CSF). C-Jun N-terminal kinases (JNKs) are serine-threonine protein kinases activated by phosphorylation and involved in neuronal death.

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