Increased orbitofrontal cortex activation associated with “pro-obsessive” antipsychotic treatment in patients with schizophrenia | Zendy

Frederike Schirmbeck | Zendy; Daniela Mier | Zendy; Christine Esslinger | Zendy; Franziska Rausch | Zendy; Susanne Englisch | Zendy; Sarah Eifler | Zendy; Andreas MeyerLindenberg | Zendy; Peter Kirsch | Zendy; Mathias Zink | Zendy

Open Access

Increased orbitofrontal cortex activation associated with “pro-obsessive” antipsychotic treatment in patients with schizophrenia

Author(s) -

Frederike Schirmbeck,

Daniela Mier,

Christine Esslinger,

Franziska Rausch,

Susanne Englisch,

Sarah Eifler,

Andreas MeyerLindenberg,

Peter Kirsch,

Mathias Zink

Publication year - 2015

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.140021

Subject(s) - orbitofrontal cortex , amisulpride , clozapine , schizophrenia (object oriented programming) , aripiprazole , psychology , antipsychotic , working memory , population , olanzapine , psychiatry , prefrontal cortex , medicine , neuroscience , cognition , environmental health

Patients with schizophrenia have an approximately 10-fold higher risk for obsessive-compulsive symptoms (OCS) than the general population. A large subgroup seems to experience OCS as a consequence of second-generation antipsychotic agents (SGA), such as clozapine. So far little is known about underlying neural mechanisms.

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