Shared intermediate phenotypes for schizophrenia and bipolar disorder: neuroanatomical features of subtypes distinguished by executive dysfunction | Zendy

Alana M. Shepherd | Zendy; Yann Quidé | Zendy; Kristin R. Laurens | Zendy; Nicole O’Reilly | Zendy; Jesseca E. Rowland | Zendy; Philip B. Mitchell | Zendy; Vaughan J. Carr | Zendy; Melissa J. Green | Zendy

Open Access

Shared intermediate phenotypes for schizophrenia and bipolar disorder: neuroanatomical features of subtypes distinguished by executive dysfunction

Author(s) -

Alana M. Shepherd,

Yann Quidé,

Kristin R. Laurens,

Nicole O’Reilly,

Jesseca E. Rowland,

Philip B. Mitchell,

Vaughan J. Carr,

Melissa J. Green

Publication year - 2015

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.130283

Subject(s) - grey matter , bipolar disorder , schizophrenia (object oriented programming) , psychology , precuneus , working memory , white matter , neuroscience , neuropsychology , audiology , cardiology , medicine , psychiatry , magnetic resonance imaging , cognition , radiology

Shared genetic vulnerability for schizophrenia and bipolar disorder may be associated with common neuroanatomical features. In view of the evidence for working memory dysfunction as a candidate intermediate phenotype for both disorders, we explored neuroanatomical distinctions between subtypes defined according to working memory (n-back task) performance.

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