Catechol-O-methyltransferase val158met genotype determines effect of reboxetine on emotional memory in healthy male volunteers | Zendy

Ayana A. Gibbs | Zendy; Carla E. Bautista | Zendy; Florence D. Mowlem | Zendy; Kris Naudts | Zendy; Dora Duka | Zendy

Open Access

Catechol-O-methyltransferase val158met genotype determines effect of reboxetine on emotional memory in healthy male volunteers

Author(s) -

Ayana A. Gibbs,

Carla E. Bautista,

Florence D. Mowlem,

Kris Naudts,

Dora Duka

Publication year - 2014

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.130131

Subject(s) - reboxetine , catechol o methyl transferase , placebo , psychology , cognition , clinical psychology , antidepressant , medicine , psychiatry , allele , reuptake inhibitor , anxiety , biochemistry , chemistry , alternative medicine , pathology , gene

Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the prefrontal cortex (PFC). A common polymorphism in the COMT gene (COMT val158met) has pleiotropic effects on cognitive and emotional processing. The met allele has been associated with enhanced cognitive processing but impaired emotional processing relative to the val allele.

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