Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats | Zendy

Weili Zhu | Zendy; Shenjun Wang | Zendy; Meng-Meng Liu | Zendy; Haishui Shi | Zendy; Ruoxi Zhang | Zendy; Jianfeng Liu | Zendy; Zengbo Ding | Zendy; Lin Lü | Zendy

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Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats

Author(s) -

Weili Zhu,

Shenjun Wang,

Meng-Meng Liu,

Haishui Shi,

Ruoxi Zhang,

Jianfeng Liu,

Zengbo Ding,

Lin Lü

Publication year - 2013

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.120228

Subject(s) - antidepressant , nmda receptor , prefrontal cortex , neuroscience , glutamatergic , pharmacology , ampa receptor , behavioural despair test , gsk 3 , neurotransmission , hippocampus , glutamate receptor , medicine , biology , receptor , kinase , biochemistry , cognition

Glutamate N-methyl-D-aspartate (NMDA) receptor antagonists exert fast-acting antidepressant effects, providing a promising way to develop a new classification of antidepressant that targets the glutamatergic system. In the present study, we examined the potential antidepressant action of 7-chlorokynurenic acid (7-CTKA), a glycine recognition site NMDA receptor antagonist, in a series of behavioural models of depression and determined the molecular mechanisms that underlie the behavioural actions of 7-CTKA.

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