Decreased cerebrospinal fluid secretogranin II concentrations in severe forms of bipolar disorder | Zendy

Joel Jakobsson | Zendy; Mats Stridsberg | Zendy; Henrik Zetterberg | Zendy; Kaj Blennow | Zendy; Carl Johan Ekman | Zendy; Anette Johansson | Zendy; Carl M. Sellgren | Zendy; Mikael Landén | Zendy

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Decreased cerebrospinal fluid secretogranin II concentrations in severe forms of bipolar disorder

Author(s) -

Joel Jakobsson,

Mats Stridsberg,

Henrik Zetterberg,

Kaj Blennow,

Carl Johan Ekman,

Anette Johansson,

Carl M. Sellgren,

Mikael Landén

Publication year - 2013

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.120170

Subject(s) - bipolar disorder , chromogranin a , cerebrospinal fluid , medicine , mood , psychology , bipolar i disorder , endocrinology , psychiatry , mania , immunohistochemistry

Bipolar disorder is a common psychiatric mood disorder that is defined by recurrent episodes of abnormally elevated mood and depression. Progressive structural brain changes in individuals with bipolar disorder have been suggested to be associated with defects in the secretion of neurotrophic factors. We sought to assess how the regulated secretory pathway in the brain is affected in patients with bipolar disorder by measuring chromogranin B and secretogranin II, which are 2 cerebrospinal fluid (CSF) biological markers for this process.

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