Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder | Zendy

Lingtao Kong | Zendy; Kaiyuan Chen | Zendy; Yanqing Tang | Zendy; Feng Wu | Zendy; Naomi Driesen | Zendy; Fay Y. Womer | Zendy; Guoguang Fan | Zendy; Ling Ren | Zendy; Wenyan Jiang | Zendy; Yang Cao | Zendy; Hilary P. Blumberg | Zendy; Ke Xu | Zendy; Fei Wang | Zendy

Open Access

Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder

Author(s) -

Lingtao Kong,

Kaiyuan Chen,

Yanqing Tang,

Feng Wu,

Naomi Driesen,

Fay Y. Womer,

Guoguang Fan,

Ling Ren,

Wenyan Jiang,

Yang Cao,

Hilary P. Blumberg,

Ke Xu,

Fei Wang

Publication year - 2013

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.120117

Subject(s) - amygdala , major depressive disorder , functional magnetic resonance imaging , psychology , prefrontal cortex , neuroscience , neural correlates of consciousness , lateralization of brain function , cognition

Convergent evidence suggests dysfunction within the prefrontal cortex (PFC) and amygdala, important components of a neural system that subserves emotional processing, in individuals with major depressive disorder (MDD). Abnormalities in this system in the left hemisphere and during processing of negative emotional stimuli are especially implicated. In this study, we used functional magnetic resonance imaging (fMRI) to investigate amygdala-PFC functional connectivity during emotional face processing in medication-naive individuals with MDD.

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