Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder | Zendy

Michelle J. Chandley | Zendy; Katalin Szebeni | Zendy; Attila Szebeni | Zendy; Jessica Crawford | Zendy; A. Stockmeier | Zendy; Gustavo Turecki | Zendy; José Javier Miguel-Hidalgo | Zendy; Gregory A. Ordway | Zendy

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Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder

Author(s) -

Michelle J. Chandley,

Katalin Szebeni,

Attila Szebeni,

Jessica Crawford,

A. Stockmeier,

Gustavo Turecki,

José Javier Miguel-Hidalgo,

Gregory A. Ordway

Publication year - 2013

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.120110

Subject(s) - locus coeruleus , glutamatergic , immunostaining , glutamate receptor , astrocyte , gene expression , neuroglia , neuroscience , endocrinology , medicine , biology , immunohistochemistry , central nervous system , gene , receptor , genetics

Norepinephrine and glutamate are among several neurotransmitters implicated in the neuropathology of major depressive disorder (MDD). Glia deficits have also been demonstrated in people with MDD, and glia are critical modulators of central glutamatergic transmission. We studied glia in men with MDD in the region of the brain (locus coeruleus; LC) where noradrenergic neuronal cell bodies reside and receive glutamatergic input.

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