Open AccessGlutamine deficiency in the prefrontal cortex increases depressive-like behaviours in male mice
Author(s) -
Younghyurk Lee,
Hyeonwi Son,
Gyeongwha Kim,
Sujeong Kim,
Dong Hoon Lee,
Gu Seob Roh,
Sang Soo Kang,
Gyeong Jae Cho,
Wan Sung Choi,
Hyun Joon Kim
Publication year - 2013
Publication title -
journal of psychiatry and neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 99
eISSN - 1488-2434
pISSN - 1180-4882
DOI - 10.1503/jpn.120024
Subject(s) - behavioural despair test , prefrontal cortex , glutamine , astrocyte , medicine , endocrinology , glutamine synthetase , glutamate receptor , infralimbic cortex , cortex (anatomy) , amino acid , psychology , chemistry , biology , neuroscience , biochemistry , hippocampus , antidepressant , receptor , central nervous system , cognition
The brain levels of glutamate (Glu) and glutamine (Gln) are partially regulated through the Glu-Gln cycle. Astrocytes play a role in regulating the Glu-Gln cycle, and loss of astrocytes has been associated with depressive disorders. We hypothesized that levels of Glu and Gln would be affected by astrocyte loss and dysregulation of the Glu-Gln cycle and that depressive-like behaviours would be closely related to the level of changes in Glu and Gln.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom