Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study | Zendy

Alexander Otti | Zendy; Harald Guendel | Zendy; Peter Henningsen | Zendy; Claus Zimmer | Zendy; Afra Wohlschläeger | Zendy; Michael NollHussong | Zendy

Open Access

Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study

Author(s) -

Alexander Otti,

Harald Guendel,

Peter Henningsen,

Claus Zimmer,

Afra Wohlschläeger,

Michael NollHussong

Publication year - 2012

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.110187

Subject(s) - default mode network , functional magnetic resonance imaging , resting state fmri , neuroscience , nociception , medicine , functional connectivity , magnetic resonance imaging , psychology , anesthesia , receptor , radiology

Without stimulation, the human brain spontaneously produces highly organized, low-frequency fluctuations of neural activity in intrinsic connectivity networks (ICNs). Furthermore, without adequate explanatory nociceptive input, patients with somatoform pain disorder experience pain symptoms, thus implicating a central dysregulation of pain homeostasis. The present study aimed to test whether interactions among pain-related ICNs, such as the default mode network (DMN), cingular-insular network (CIN) and sensorimotor network (SMN), are altered in somatoform pain during resting conditions.

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