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Hippocampal abnormalities of glutamate/glutamine, N-acetylaspartate and choline in patients with depression are related to past illness burden
Author(s) -
Javier de Diego-Adeliño,
Marı́a J. Portella,
Beatriz GómezAnsón,
Olga López-Moruelo,
Maria Serra-Blasco,
Yolanda VivesGilabert,
Dolors Puigdemont,
Rosario PérezEgea,
E. Álvarez,
Víctor Pérez
Publication year - 2013
Publication title -
journal of psychiatry and neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.767
H-Index - 99
eISSN - 1488-2434
pISSN - 1180-4882
DOI - 10.1503/jpn.110185
Subject(s) - depression (economics) , glutamine , hippocampus , medicine , hippocampal formation , choline , glutamate receptor , major depressive disorder , endocrinology , amygdala , biology , receptor , biochemistry , macroeconomics , amino acid , economics
Smaller hippocampal volumes in major depressive disorder (MDD) have been linked with earlier onset, previous recurrences and treatment refractoriness. The aim of our study was to investigate metabolite abnormalities in the hippocampus associated with past depressive illness burden.

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