Structural brain correlates of sensorimotor gating in antipsychotic-naive men with first-episode schizophrenia | Zendy

Trine Bjørg Hammer | Zendy; Bob Oranje | Zendy; Arnold Skimminge | Zendy; Bodil Aggernæs | Zendy; Bjørn H. Ebdrup | Zendy; Birte Glenthøj | Zendy; William F.C. Baaré | Zendy

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Structural brain correlates of sensorimotor gating in antipsychotic-naive men with first-episode schizophrenia

Author(s) -

Trine Bjørg Hammer,

Bob Oranje,

Arnold Skimminge,

Bodil Aggernæs,

Bjørn H. Ebdrup,

Birte Glenthøj,

William F.C. Baaré

Publication year - 2012

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.110129

Subject(s) - prepulse inhibition , grey matter , psychology , premotor cortex , neuroscience , schizophrenia (object oriented programming) , psychosis , magnetic resonance imaging , white matter , medicine , psychiatry , dorsum , anatomy , radiology

Prepulse inhibition (PPI) of the startle reflex is modulated by a complex neural network. Prepulse inhibition impairments are found at all stages of schizophrenia. Previous magnetic resonance imaging (MRI) studies suggest that brain correlates of PPI differ between patients with schizophrenia and healthy controls; however, these studies included only patients with chronic illness and medicated patients. Our aim was to examine the structural brain correlates of PPI in antipsychotic-naive patients with first-episode schizophrenia.

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