Association between the NMDA glutamate receptor GRIN2B gene and obsessive–compulsive disorder | Zendy

Pino Alonso | Zendy; Mónica Gratacòs | Zendy; Cinto Segalàs | Zendy; Geòrgia Escaramís | Zendy; Eva Real | Zendy; Mónica Bayés | Zendy; Javier Labad | Zendy; Clara LópezSolà | Zendy; Xavier Estivill | Zendy; José M. Menchón | Zendy

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Association between the NMDA glutamate receptor GRIN2B gene and obsessive–compulsive disorder

Author(s) -

Pino Alonso,

Mónica Gratacòs,

Cinto Segalàs,

Geòrgia Escaramís,

Eva Real,

Mónica Bayés,

Javier Labad,

Clara LópezSolà,

Xavier Estivill,

José M. Menchón

Publication year - 2012

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.110109

Subject(s) - haplotype , single nucleotide polymorphism , odds ratio , snp , glutamatergic , genetic association , genetics , medicine , allele , psychiatry , genotype , biology , glutamate receptor , gene , receptor

Recent data from neuroimaging, genetic and clinical trials and animal models suggest a role for altered glutamatergic neuro transmission in the pathogenesis of obsessive-compulsive disorder (OCD). The aim of this study was to investigate whether variants in the GRIN2B gene, the gene encoding the NR2 subunit of the N-methyl-D-aspartate (NMDA) glutamate receptor, may contribute to genetic susceptibility to OCD or to different OCD subphenotypes.

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