Ionotropic glutamate receptor mRNA editing in the prefrontal cortex: no alterations in schizophrenia or bipolar disorder | Zendy

Rebecca Lyddon | Zendy; Scott Navarrett | Zendy; Stella Dracheva | Zendy

Open Access

Ionotropic glutamate receptor mRNA editing in the prefrontal cortex: no alterations in schizophrenia or bipolar disorder

Author(s) -

Rebecca Lyddon,

Scott Navarrett,

Stella Dracheva

Publication year - 2012

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.110107

Subject(s) - bipolar disorder , rna editing , ampa receptor , schizophrenia (object oriented programming) , ionotropic effect , glutamate receptor , psychosis , psychiatry , neuroscience , biology , psychology , medicine , genetics , mood , rna , receptor , gene

Dysfunction of glutamate neurotransmission has been implicated in the pathology of schizophrenia and bipolar disorder, and one mechanism by which glutamate signalling can be altered is through RNA editing of ionotropic glutamate receptors (iGluRs). The objectives of the present study were to evaluate the editing status of iGluRs in the human prefrontal cortex, determine whether iGluR editing is associated with psychiatric disease or suicide and evaluate a potential association between editing and alternative splicing in the α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) iGluR subunits' pre-mRNA.

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