Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster | Zendy

Manreena Kaur | Zendy; Robert Battisti | Zendy; Jim Lagopoulos | Zendy; Philip B. Ward | Zendy; Ian B. Hickie | Zendy; Daniel F. Hermens | Zendy

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Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster

Author(s) -

Manreena Kaur,

Robert Battisti,

Jim Lagopoulos,

Philip B. Ward,

Ian B. Hickie,

Daniel F. Hermens

Publication year - 2012

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.110081

Subject(s) - mismatch negativity , p3a , bipolar disorder , psychology , schizophrenia (object oriented programming) , schizophreniform disorder , psychosis , schizoaffective disorder , schizophrenia spectrum , psychiatry , audiology , psychosocial , clinical psychology , cognition , electroencephalography , medicine

Mismatch negativity (MMN) and P3a are event-related potentials that index deviance detection and the orienting response, respectively. We have previously shown that the MMN/P3a complex is impaired in patients with schizophrenia and affective spectrum psychoses, which suggests that it may index a common pathophysiology and argues against the purported specificity in schizophrenia. Further research is warranted to determine whether patients with bipolar-spectrum disorders show similar impairments in these biomarkers.

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