Brain functional connectivity during induced sadness in patients with obsessive–compulsive disorder | Zendy

Leonardo F. Fontenelle | Zendy; Ben J. Harrison | Zendy; Jesús Pujol | Zendy; Christopher G. Davey | Zendy; Alex Fornito | Zendy; Emre Bora | Zendy; Christos Pantelis | Zendy; Murat Yücel | Zendy

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Brain functional connectivity during induced sadness in patients with obsessive–compulsive disorder

Author(s) -

Leonardo F. Fontenelle,

Ben J. Harrison,

Jesús Pujol,

Christopher G. Davey,

Alex Fornito,

Emre Bora,

Christos Pantelis,

Murat Yücel

Publication year - 2012

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.110074

Subject(s) - anterior cingulate cortex , sadness , mood , psychology , ventral striatum , functional magnetic resonance imaging , neuroscience , mood disorders , neuroimaging , anxiety , cognition , psychiatry , striatum , anger , dopamine

Obsessive-compulsive disorder (OCD) is associated with a range of emotional abnormalities linked to its defining symptoms, comorbid illnesses and cognitive deficits. The aim of this preliminary study was to examine functional changes in the brain that are associated with experimentally induced sad mood in patients with OCD compared with healthy controls in a frontolimbic circuit relevant to both OCD and mood regulation.

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