Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive–compulsive disorder | Zendy

Christine Löchner | Zendy; JeanPaul Fouché | Zendy; Stéfan du Plessis | Zendy; Bruce Spottiswoode | Zendy; Soraya Seedat | Zendy; Naomi Fineberg | Zendy; Samuel R. Chamberlain | Zendy; Dan J. Stein | Zendy

Open Access

Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive–compulsive disorder

Author(s) -

Christine Löchner,

JeanPaul Fouché,

Stéfan du Plessis,

Bruce Spottiswoode,

Soraya Seedat,

Naomi Fineberg,

Samuel R. Chamberlain,

Dan J. Stein

Publication year - 2012

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.110059

Subject(s) - fractional anisotropy , cingulum (brain) , white matter , internal capsule , diffusion mri , corpus callosum , psychology , anxiety , medicine , cardiology , psychiatry , magnetic resonance imaging , neuroscience , radiology

There is evidence to suggest that obsessive-compulsive disorder (OCD) is associated with structural abnormalities in cortico-striato-thalamic circuits, yet the extent of white matter abnormalities is not well established. In this study, we used diffusion tensor imaging (DTI) to examine white matter integrity in specific regions of interest (ROIs) in patients with OCD.

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