Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression | Zendy

Thomas Frodl | Zendy; Angela Carballedo | Zendy; Andrew Fagan | Zendy; Danuta Lisiecka | Zendy; Yolande Ferguson | Zendy; James F. Meaney | Zendy

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Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression

Author(s) -

Thomas Frodl,

Angela Carballedo,

Andrew Fagan,

Danuta Lisiecka,

Yolande Ferguson,

James F. Meaney

Publication year - 2011

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.110028

Subject(s) - fractional anisotropy , splenium , corpus callosum , fornix , superior longitudinal fasciculus , late life depression , white matter , psychology , tractography , inferior longitudinal fasciculus , uncinate fasciculus , major depressive disorder , depression (economics) , psychiatry , clinical psychology , medicine , neuroscience , magnetic resonance imaging , cognition , hippocampus , macroeconomics , economics , radiology

Relatives of patients with major depressive disorder (MDD) and people who experienced early-life adversity are at risk for MDD. The aim of our study was to investigate whether unaffected first-degree healthy relatives (UHRs) of patients with MDD show changes in white matter fibre connections compared with healthy controls and whether there are interactions between early-life adversity and these microstructural changes.

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