Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and the personality trait psychoticism? | Zendy

Petra Suchankova | Zendy; Jonas Klang | Zendy; Carin Cavanna | Zendy; Göran Holm | Zendy; Staffan Nilsson | Zendy; Erik G. Jönsson | Zendy; Agneta Ekman | Zendy

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Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and the personality trait psychoticism?

Author(s) -

Petra Suchankova,

Jonas Klang,

Carin Cavanna,

Göran Holm,

Staffan Nilsson,

Erik G. Jönsson,

Agneta Ekman

Publication year - 2012

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.110024

Subject(s) - psychoticism , schizophrenia (object oriented programming) , personality , population , psychology , neuroticism , psychosis , big five personality traits , clinical psychology , medicine , psychiatry , extraversion and introversion , social psychology , environmental health

The receptor for advanced glycation end products (RAGE) is the main receptor for S100B, an astrogial proinflammatory mediator that has been suggested to be involved in the pathophysiology of schizophrenia. To further elucidate the possible relevance of inflammation for mental functions, we investigated a functional polymorphism in the gene coding for RAGE in relation to personality traits and susceptibility to schizophrenia.

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