Topiramate diminishes fear memory consolidation and extinguishes conditioned fear in rats | Zendy

Pedro Antônio Schmidt do PradoLima | Zendy; Myriam Fortes Perrenoud | Zendy; Christian Haag Kristensen | Zendy; Martı́n Cammarota | Zendy; Iván Izquierdo | Zendy

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Topiramate diminishes fear memory consolidation and extinguishes conditioned fear in rats

Author(s) -

Pedro Antônio Schmidt do PradoLima,

Myriam Fortes Perrenoud,

Christian Haag Kristensen,

Martı́n Cammarota,

Iván Izquierdo

Publication year - 2011

Publication title -

journal of psychiatry and neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.767

H-Index - 99

eISSN - 1488-2434

pISSN - 1180-4882

DOI - 10.1503/jpn.100115

Subject(s) - memory consolidation , extinction (optical mineralogy) , topiramate , psychology , consolidation (business) , neuroscience , conditioning , anesthesia , developmental psychology , medicine , hippocampus , epilepsy , chemistry , mineralogy , statistics , mathematics , accounting , business

Topiramate has been recognized as a drug that can induce memory and cognitive impairment. Using the one-trial inhibitory avoidance task, we sought to verify the effect of topiramate on consolidation and extinction of aversive memory. Our hypothesis was that topiramate inhibits the consolidation and enhances the extinction of this fear memory.

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