Meta-analytic comparison of randomized and nonrandomized studies of breast cancer surgery
Author(s) -
Janet Edwards,
Elizabeth Kelly,
Yongtao Lin,
Taryn J. Lenders,
William A. Ghali,
Andrew Graham
Publication year - 2012
Publication title -
canadian journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.609
H-Index - 64
eISSN - 1488-2310
pISSN - 0008-428X
DOI - 10.1503/cjs.023410
Subject(s) - medicine , randomized controlled trial , breast cancer , medline , meta analysis , cochrane library , relative risk , surgery , cancer , confidence interval , political science , law
Randomized controlled trials (RCTs) are thought to provide the most accurate estimation of "true" treatment effect. The relative quality of effect estimates derived from nonrandomized studies (nRCTs) remains unclear, particularly in surgery, where the obstacles to performing high-quality RCTs are compounded. We performed a meta-analysis of effect estimates of RCTs comparing surgical procedures for breast cancer relative to those of corresponding nRCTs.
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