Results of Octaplex for reversal of warfarin anticoagulation in patients with hip fracture | Zendy

Richard Ng | Zendy; MeerTaher ShabaniRad | Zendy

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Results of Octaplex for reversal of warfarin anticoagulation in patients with hip fracture

Author(s) -

Richard Ng,

MeerTaher ShabaniRad

Publication year - 2019

Publication title -

canadian journal of surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.609

H-Index - 64

eISSN - 1488-2310

pISSN - 0008-428X

DOI - 10.1503/cjs.018017

Subject(s) - medicine , warfarin , hip fracture , surgery , orthopedic surgery , fresh frozen plasma , anesthesia , osteoporosis , atrial fibrillation , platelet

Patients with hip fracture who present anticoagulated with warfarin often require reversal of anticoagulation for safe hip fracture surgery. Vitamin K is typically administered for this, but requires 24-48 hours for maximal effect. These patients have an increased delay to surgery and increased mortality. Octaplex is a prothrombin complex concentrate (PCC) that reverses warfarin anticoagulation in less than an hour. This study assesses the effectiveness and safety of Octaplex for reversal of warfarin anticoagulation for hip fracture surgery.

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