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Results: 702 women with only maternal age risk and 324 women with combined age and biochemical risk were included in study (1026 in total). Mean age of the study population was 38,11±2,66. Biochemical risk group had 27 fetuses (8,3%) with Trisomy 21 while advanced age only risk group had 18 fetuses (2,5%) diagnosed with Trisomy 21. When added to age factor, biochemical factors increased detection of Trisomy 21 significantly (Odds ratio : 3,56 p <0,001 ).

Amniocentesis results according to risk factors: a result of 1026 women with advanced maternal age