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Amac: Bu calismada, bazi yeni oksazolidinon turevlerinin antimikrobiyal etkileri S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, metisilin-direncli Staphylococcus aureus (MRSA) klinik izolati ve C. albicans ATCC 10231’e karsi incelenmistir. Gerec ve Yontem: Daha once elde edilen ve yayinlanan 10 oksazolidinonlarin antimikrobiyal aktivitesi test edilmistir ve calisma Mueller-Hinton broth ve Sabouraud dekstroz broth icinde gerceklestirilmistir. Sonuc ve Tartisma: E5 ve E9 bilesikleri, sirasiyla, 25 μg/mL ve 50 μg/mL ile hem bakteri hem de mantarlara karsi antimikrobiyal aktivite gostermistir. Bizim bu arastirmamiz ve diger bazi calismalar, elektro-negatiflik derecesinin biyolojik aktivite icin cok onemli oldugunu gostermistir.

A research for some oxazolidinones to evaluate their antimicrobial activity