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Taksan sinifi bilesikler (paklitaksel ve dosetaksel) son yillarin en onemli kanser kemoterapotiklerindendir. Mikrotubullerin stabil halde kalmasini saglayan paklitaksel, ilk defa ABD'de yetisen Taxus brevifolia Nutt.'nin kabugundan 1971 yilinda elde edilmistir. Dosetaksel, Avrupa'da yetisen Taxus baccata'nin yapraklarindan ekstre edilen 10-deasetilbakkatin III'den yarisentez sonucu elde edilmistir. Her iki ilac benzer etki mekanizmasi, preklinik ve klinik aktivitelere sahiptir. Bu makalede, paklitaksel (Taxol ) ve dosetaksel (Taxotere ) uzerinde son yillarda yapilan klinik arastirmalar ve yapi-aktivite iliskilerine ait bilgiler verilmektedir

TAKSAN SINIFI BİLEŞİKLERİN ANTİTÜMÖR ETKİLERİ :THE ANTITUMOR EFFECTS OF THE TAXANE CLASS COMPOUNDS