RNA Processing and Ribosome Biogenesis in Bone Marrow Failure Disorders | Zendy

William L. Blalock | Zendy; Manuela Piazzi | Zendy; Angela Gallo | Zendy; Alberto Bavelloni | Zendy; Enrico Focaccia | Zendy; Irene Faenza | Zendy

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RNA Processing and Ribosome Biogenesis in Bone Marrow Failure Disorders

Author(s) -

William L. Blalock,

Manuela Piazzi,

Angela Gallo,

Alberto Bavelloni,

Enrico Focaccia,

Irene Faenza

Publication year - 2017

Publication title -

rna and disease

Language(s) - English

Resource type - Journals

ISSN - 2375-2467

DOI - 10.14800/rd.1531

Subject(s) - biogenesis , ribosome biogenesis , rna , bone marrow , ribosome , biology , computational biology , genetics , bioinformatics , immunology , gene

Bone marrow failure disorders (BMFDs), which are characterized by an early pro-apoptotic phase which results in faulty hematopoiesis and anemia, more often than not progress to outright acute myelogenous leukemia (AML). Recent findings have indicated that most if not all of these disorders have a very significant RNA processing component to their pathology. This review aims to highlight some of normal processes of RNA metabolism that have been recently demonstrated to be altered in BMFDs.

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