Oligophrenin-1: the link between calcium-regulated exocytosis and compensatory endocytosis in neuroendocrine cells | Zendy

Catherine Estay-Ahumada | Zendy; Stéphane Ory | Zendy; Stéphane Gasman | Zendy; Sébastien Houy | Zendy

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Oligophrenin-1: the link between calcium-regulated exocytosis and compensatory endocytosis in neuroendocrine cells

Author(s) -

Catherine Estay-Ahumada,

Stéphane Ory,

Stéphane Gasman,

Sébastien Houy

Publication year - 2016

Publication title -

neuroscience communications

Language(s) - English

Resource type - Journals

ISSN - 2470-4008

DOI - 10.14800/nc.1251

Subject(s) - exocytosis , endocytosis , microbiology and biotechnology , secretory vesicle , biology , bulk endocytosis , endocytic cycle , secretion , vesicle , munc 18 , calcium , endocrinology , medicine , membrane , cell , biochemistry , synaptic vesicle

In neuroendocrine cells, hormones and neuropeptides are released from large-dense core vesicles (secretory granules) by calcium-regulated exocytosis. Following exocytosis, compensatory uptake of membrane is required to maintain membrane homeostasis and allow recycling of secretory vesicle membranes. How these cells initiate and regulate this compensatory endocytosis remains poorly understood. Our recent data suggests that oligophrenin-1 (OPHN1) is a link coupling calcium-regulated exocytosis to compensatory endocytosis of secretory granules in the adrenal chromaffin cells (Houy et al., 2015, J Neurosci. 2015, 35:11045-55). Here, we highlight the major evidence and discuss how OPHN1 could couple these two processes.

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