Spirooxindoles, a potential novel class of anti-inflammatory agents

In a previous study, we reported a class of spirooxindole-pyranopyrimidine compounds that exhibited broad spectrum anti-cancer activity. In a most recent study, we found that one of these compounds, JP-8g, also showed potent in vivo anti-inflammatory activity. In vitro and in vivo experiments suggested that JP-8g exerts this activity through nitric oxide (NO) signaling pathway. Herein, we discuss the potential of the use of these compounds as anti-inflammatory agents. The new data in this study also suggested that NF-kB signaling pathway is not involved in the anti-inflammatory activity of JP-8g.