Research Highlight: Chronic sustained inflammation links to left ventricular hypertrophy and aortic valve sclerosis: a new link between S100/RAGE and FGF23 | Zendy

Ling Yan | Zendy; Marion A. Hofmann Bowman | Zendy

Open Access

Research Highlight: Chronic sustained inflammation links to left ventricular hypertrophy and aortic valve sclerosis: a new link between S100/RAGE and FGF23

Author(s) -

Ling Yan,

Marion A. Hofmann Bowman

Publication year - 2014

Publication title -

inflammation and cell signaling

Language(s) - English

Resource type - Journals

ISSN - 2330-7803

DOI - 10.14800/ics.279

Subject(s) - medicine , left ventricular hypertrophy , s100 protein , cardiology , inflammation , immunohistochemistry , blood pressure

Cardiovascular disease including left ventricular hypertrophy, diastolic dysfunction and ectopic valvular calcification are common in patients with chronic kidney disease (CKD). Both S100A12 and fibroblast growth factor 23 (FGF23) have been identified as biomarkers of cardiovascular morbidity and mortality in patients with CKD. We tested the hypothesis that human S100/calgranulin would accelerate cardiovascular disease in mice subjected to CKD.

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