The protect role of Hydrogen sulfide in gastric injury

Hydrogen sulfide (H 2 S), an endogenously produced gasotransmitter, which is soluble in both water and lipids, is now known for its protective effects against various disease models and cellular injuries. This article focus on the protective effects of H 2 S on gastric injury and the currently known signaling mechanisms underlying these protective effects, based on existing literature. H 2 S, whether of endogenous or exogenous origin, have protective effect on gastric mucosa injury and can accelerate ulcer healing. H 2 S exert its protective effect through anti-inflammation, anti-oxidative or anti-apoptosis. These features make H 2 S a potential therapeutic value in acute gastric mucosal lesion and a particularly attractive molecule to exploit in the development of new anti-gastric injury drugs.