Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity | Zendy

Jian Zhang | Zendy; Qingjun Liu | Zendy; Wallace Y. Langdon | Zendy

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Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity

Author(s) -

Jian Zhang,

Qingjun Liu,

Wallace Y. Langdon

Publication year - 2014

Publication title -

inflammation and cell signaling

Language(s) - English

Resource type - Journals

ISSN - 2330-7803

DOI - 10.14800/ics.146

Subject(s) - phosphocholine , inflammation , macrophage polarization , medicine , macrophage , immunology , cancer research , chemistry , in vitro , phosphatidylcholine , biochemistry , phospholipid , membrane

Cbl-b is a member of the Cbl family of RING finger E3 ubiquitin ligases and polymorphisms and mutations in Cbl-b are associated with several autoimmune/inflammatory diseases in humans. Furthermore, gene targeting experiments in mice have provided proof of the in vivo effects of Cbl-b on T cell function and its involvement with these diseases. This brief review updates our understanding of Cbl-b in T cell tolerance, proallergic T cell development, and cancer immunity in light of the most recent advances, and their impact on autoimmune-/inflammatory diseases and cancer immunotherapy.

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