Prussian blue nanoparticles possess potential anti-inflammatory properties via scavenging reactive oxygen species

Iron-based nanomaterials are thought to be cytotoxic in recent researches due to the mechanism that they can produce hydroxyl radical (•OH) in cells via Fenton reaction. However, we found Prussian blue nanoparticles (PBNPs) possess reactive oxygen species (ROS) scavenging ability due to their peroxidase (POD), catalase (CAT), super-oxide dismutase (SOD)-like activities and affinity for •OH. We theorized the multienzyme-like activities of PBNPs were caused by their abundant redox potentials in different forms: Prussian White (PW), Prussian blue (PB), Berlin Green (BG) and Prussian Yellow (PY), what makes them admirable electron transporters. The reported PBNPs show anti-inflammation ability in lipopolysaccharide (LPS)-induced cell and animal inflammation research endeavors.