Cytidine deaminase as a molecular target in cancer: an insight

Cancer is one of the leading causes of death globally. Although more than 400 varieties of cancer have been reported, based on cell lines, still the actual reason of all types of cancer is not very clear. Several internal and external factors have been identified and the study is ongoing. Up to now about 73 proteins have been identified that are capable to influence directly various phases of cancer including mutation, cell proliferation, invasion, angiogenesis, and metastasis. Cytidine deaminase is one of the important proteins that is responsible for various types of cancer that includes gastric, liver, biliary tract, bladder, breast, pancreatic ductal adenocarcinoma (PDAC) and so on. Two excellent inhibitors of cytidine deaminase are commercially available. A brief overview is presented in this advanced review. Any omission is completely unintentional.