Open AccessTherapeutic Transdifferentiation: Can we Generate Cardiac Tissue Rather Than Scar after Myocardial Injury?
Author(s) -
Nazish Sayed,
Wing Tak Wong,
John P. Cooke
Publication year - 2013
Publication title -
methodist debakey cardiovascular journal
Language(s) - English
Resource type - Journals
eISSN - 1947-6094
pISSN - 1947-6108
DOI - 10.14797/mdcj-9-4-210
Subject(s) - medicine , medline , medical education , law , political science
After myocardial injury, the cardiac muscle does not regenerate and heals by forming a scar. This process results in loss of heart function and ultimately heart failure. Recent application of reprogramming technology, where forced expression of master regulators convert scar-forming cells to become cardiovascular cells in vivo, has fueled new hope for the development of therapies targeting heart disease.