A Combined Bioinformatics and Literature Based Approach for Identification of Long Non-coding RNAs That Modulate Vitamin D Receptor Signaling in Breast Cancer | Zendy

Vahid Kholghi Oskooei | Zendy; Soudeh GhafouriFard | Zendy; Davood Omrani Mir | Zendy

Open Access

A Combined Bioinformatics and Literature Based Approach for Identification of Long Non-coding RNAs That Modulate Vitamin D Receptor Signaling in Breast Cancer

Author(s) -

Vahid Kholghi Oskooei,

Soudeh GhafouriFard,

Davood Omrani Mir

Publication year - 2018

Publication title -

klinicka onkologie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.204

H-Index - 13

eISSN - 1802-5307

pISSN - 0862-495X

DOI - 10.14735/amko2018264

Subject(s) - calcitriol receptor , in silico , biology , signal transduction , carcinogenesis , computational biology , vitamin d and neurology , calcitriol , bioinformatics , transcriptome , cancer research , receptor , cancer , gene , microbiology and biotechnology , gene expression , genetics , endocrinology

Long non-coding RNAs (lncRNAs) as an important fraction of human transcriptome have been shown to exert fundamental role in regulation of signaling pathways implicated in carcinogenesis. Among them is vitamin D receptor (VDR) signaling whose participation in various cancers including breast cancer (BC) is evident. In spite of the presence of several evidences for participation of lncRNAs as well as VDR signaling in BC pathogenesis, no comprehensive study has evaluated the link between lncRNA dysregulation and VDR signaling in BC.

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