Perinatal Stroke Associated with Placental Chorioangioma: A Rare Case and Review of Literature

Departments of Obstetrics and Gynecology, Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Placental chorioangioma is the most common non-trophoblastic and hamartoma-like tumor and has generally good prognosis if the size is small. The incidence of a placental chorioangioma is an estimated 1% of all deliveries. The size of a chorioangioma is considered significant if it is larger than 4 cm, since fetal compromise can occur due to circulatory overload. Very rarely, a placental chorioangioma can directly exert fetal circulation to cause fetal cerebral ischemic stroke, especially in giant placental chorioangiomas which are defined as more than 4-5 cm in diameter. Here, we report a case of a huge chorioangioma, sized 7×5 cm with thrombo-occlusion in the placenta associated with neonatal stroke. Perinatal stroke and giant placental chorioangioma are each very rare. Moreover, the combination is extremely rare as is expected. Our case implicates that placental examination should be considered as an important diagnostic workup in cases of perinatal stroke with unknown etiology.