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Experimental study of the effects of Ulinastatin on reducing MDA in free flaps
Author(s) -
Wei Lü,
Ruixia Qi,
Yifan Sun,
Yafan Sun,
Mingjuan Gu,
Xiang Gao,
Peng Yu,
Jing Sun
Publication year - 2016
Publication title -
discussion of clinical cases
Language(s) - English
Resource type - Journals
eISSN - 2375-8449
pISSN - 2375-8473
DOI - 10.14725/dcc.v3n3p9
Subject(s) - ulinastatin , medicine , surgery , free flap , thrombosis , anastomosis , contracture , ischemia , stenosis , inflammation , transplantation , microcirculation , infiltration (hvac) , necrosis , anesthesia , pathology , physics , thermodynamics
Free flap transplantation is the most important plastic surgery treatment. Although free flap is an important tissue repair tool for plastic surgery, it is easy to happen due to the anastomotic stenosis or thrombosis, as well as the inflammatory reaction caused by ischemia-reperfusion injury of the flap and the inflammation caused by these inflammatory reactions. Microcirculation contracture or occlusion will lead to partial or complete flap necrosis, thus affecting the repair effect. Numerous studies show that neutrophils are closely involved in the process of ischemic injury of free flaps. The purpose of this experiment is to investigate the use of ulinastatin to inhibit the inflammatory infiltration of free flaps to improve the survival of the flap.

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