Experimental study of kidney protective effects of sanhuangshaoshangling on severe burn rats in shock stage

Objective: To observe the protective effects and mechanisms of topical Chinese medicine on kidneys of severe burns shock rats. Methods: Blood urea nitrogen (Bun), creatinine (Cr), myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α) and interleukin (IL-6), were checked by the time points of 8, 24, 48 hours. Blood tests, ELISA and other methods were used for these texts. Results: Compared with the povidone-iodine group, the levels of Bun and Cr were declined apparently in the Sanhuang group, and the activity of MPO was decreased as well. Conclusions: Sanhuangshaoshangling, taking ointment as matrix, can be externally applied to wounds. It contains some effective ingredients which can clear heat-toxicity and promote blood circulation for removing blood stasis, and prevents wounds from the stimulation of the air to nerve endings and the invasion of bacteria. It can also inhibit bacteria from parasitizing, growing, reproducing on the wound. Sanhuangshaoshangling helps blood circulation and facilitates the growth of tissues to inactivate the toxicity or reduce toxin by changing the structure of endotoxin after uptake into tissues. It can protect viscera by reducing the release of endotoxin, facilitating the excretion of endotoxin and weakening or eliminating the effects of TNF-α and IL-6.