Alternative Methods: 3Rs, Research and Regulatory Aspects

378 Alternative Methods: 3Rs, Research and Regulatory Aspects Francesca Caloni 1, Patrizia Costa , Gianni Dal Negro 3, Isabella De Angelis 4, Silvia Dotti 5, Giovanna Lazzari 6, Giacomo Metteucci 7, and Augusto Vitale 8 Universita degli Studi di Milano, Department of Health, Animal Science and Food Safety, Milan, Italy; Universita degli studi di Milano, laboratory Animal Science and Medicine Specialization School, Milan, Italy; GlaxoSmithKline RD Istituto Superiore di Sanita, ISS, Department of environment and Primary Prevention, Rome, Italy; Istituto Zooprofilattico Sperimentale della lombardia e dell’emilia Romagna “Bruno Ubertini” (IZSleR), Brescia, Italy; Avantea, laboratory of Reproductive technologies, Cremona, Italy; Universita degli studi di Milano, lAS and Animal Welfare Consultant, Milan, Italy; Istituto Superiore di Sanita, ISS; Department of Cell Biology and Neuroscience, Section of Behavioural Neuroscience, Rome, Italy