Replacing, reducing and refining the use of animals in tuberculosis vaccine research | Zendy

Rachel Tanner | Zendy

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Replacing, reducing and refining the use of animals in tuberculosis vaccine research

Author(s) -

Rachel Tanner

Publication year - 2016

Publication title -

altex

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.975

H-Index - 51

eISSN - 1868-8551

pISSN - 1868-596X

DOI - 10.14573/altex.1607281

Subject(s) - tuberculosis , tuberculosis vaccines , context (archaeology) , mycobacterium tuberculosis , medicine , intensive care medicine , disease , mycobacterium bovis , immunology , virology , environmental health , biology , pathology , paleontology

Tuberculosis (TB) remains a serious global health threat and an improved vaccine is urgently needed. New candidate TB vaccines are tested using preclinical animal models such as mice, guinea pigs, cattle and non-human primates. Animals are routinely infected with virulent Mycobacterium tuberculosis (Mtb) in challenge experiments to evaluate protective efficacy, raising ethical issues regarding the procedure of infection itself, symptoms of disease and humane end-points. We summarize the importance and limitations of animal models in TB vaccine research and review current alternatives and modifications in the context of the NC3Rs framework for replacing, reducing and refining the use of animals for scientific purposes.

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