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The Role of In Silico Tools in Supporting the Application of the Substitution Principle Alessandra Roncaglioni 1, Emilio Benfenati 1, Alberto Mantovani 2, Ferdinando Fiorino 3, Elisa Perissutti 3 and Stefano Lorenzetti 2 Istituto di Ricerche Farmacologiche “Mario Negri” (IRFMN), Department of Environmental Health Sciences, Laboratory of Environmental Toxicology and Chemistry, Milan, Italy; Istituto Superiore di Sanità (ISS), Department of Food Safety and Veterinary Public Health, Rome, Italy; Università degli Studi di Napoli “Federico II”, Department of Pharmacy, Naples, Italy

The role of in silico tools in supporting the application of the substitution principle