Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action | Zendy

Catherine Willett | Zendy; Jessica Caverly Rae | Zendy; Katy O. Goyak | Zendy; Gary D. Minsavage | Zendy; Carl Westmoreland | Zendy; Melvin E. Andersen | Zendy; Mark Avigan | Zendy; Daniel Duché | Zendy; Georgina Harris | Zendy; Thomas Härtung | Zendy; Hartmut Jaeschke | Zendy; André Kleensang | Zendy; Brigitte Landesmann | Zendy; Suzanne N. Martos | Zendy; Marilyn Matevia | Zendy; Colleen Toóle | Zendy; Andrew Rowan | Zendy; T.W. Schultz | Zendy; Jennifer Seed | Zendy; John M. Senior | Zendy; Imran Shah | Zendy; Kalyanasundaram Subramanian | Zendy; Mathieu Vinken | Zendy; Paul B. Watkins | Zendy

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Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action

Author(s) -

Catherine Willett,

Jessica Caverly Rae,

Katy O. Goyak,

Gary D. Minsavage,

Carl Westmoreland,

Melvin E. Andersen,

Mark Avigan,

Daniel Duché,

Georgina Harris,

Thomas Härtung,

Hartmut Jaeschke,

André Kleensang,

Brigitte Landesmann,

Suzanne N. Martos,

Marilyn Matevia,

Colleen Toóle,

Andrew Rowan,

T.W. Schultz,

Jennifer Seed,

John M. Senior,

Imran Shah,

Kalyanasundaram Subramanian,

Mathieu Vinken,

Paul B. Watkins

Publication year - 2014

Publication title -

altex

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.975

H-Index - 51

eISSN - 1868-8551

pISSN - 1868-596X

DOI - 10.14573/altex.1401281

Subject(s) - adverse outcome pathway , action (physics) , liver toxicity , process (computing) , human health , european commission , engineering ethics , computer science , medicine , computational biology , engineering , biology , toxicity , business , european union , environmental health , physics , quantum mechanics , operating system , economic policy

A workshop sponsored by the Human Toxicology Project Consortium (HTPC), "Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action" brought together experts from a wide range of perspectives to inform the process of pathway development and to advance two prototype pathways initially developed by the European Commission Joint Research Center (JRC): liver-specific fibrosis and steatosis. The first half of the workshop focused on the theory and practice of pathway development; the second on liver disease and the two prototype pathways. Participants agreed pathway development is extremely useful for organizing information and found that focusing the theoretical discussion on a specific AOP is extremely helpful. In addition, it is important to include several perspectives during pathway development, including information specialists, pathologists, human health and environmental risk assessors, and chemical and product manufacturers, to ensure the biology is well captured and end use is considered.

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